http://repository.vnu.edu.vn/handle/VNU_123/28877
Despite
Polygonum multiflorum (PM) has been experiencely used as a drug to treat early
graying hair phenomenon in Asian countries for a long time, there is limited
study examined the real biological effects of PM on hair graying in vitro and
in vivo.
In
this study, we investigated the effects of PM root extract (PM-RE) on melanin
synthesis in human melanoma SKMEL-28 cells and embryos/larvae of wild-type
strain AB zebrafish.
We
also preliminary revealed the molecular mechanism of early hair graying
phenomenon in both in vitro and in vivo models.
Our
results showed that PM-RE significantly induced melanin synthesis in
melanin-producing SKMEL-28 melanoma cells and also in zebrafish embryos/larvae
at 4-day postfertilization through activation of MC1R/MITF/tyrosinase-signaling
pathway.
We
also investigated the differences in genotype between graying hair follicle and
black hair follicle of young peoples and found that early hair graying
phenomenon may be related to downregulation of MC1R/MITF/tyrosinase pathway.
Taken
together, we suggested that PM-RE at safe doses could be used as a potential
agent for the treatment of early hair graying and other loss
pigmentation-related diseases.
Title:
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